American Pie sativa-dominant weed strain is a unique strain with effects that give users a cerebral, happy, and uplifting experience. This strain can help to alleviate anxiety, chronic pain, depression, irritability, migraines and stress. Medical conditions American Pie can help treat include stress, anxiety, depression, chronic pain as well as headaches related to migraines. American Pie is bred by Pyramid Seeds of Barcelona, it is a delicious hybrid strain that was created from crossing Power Plant and White Widow. Its aroma is sweet yet slightly fruity with just a hint of pine.